Dimethyl Sulfate → HCID 20515167, compound

HRID 839652Notes

Reaction equation

HRID 839652 reaction equation
[SH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[OH-].[Na+].S(OC)(O[CH3:27])(=O)=O>O>[CH3:27][S:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 20515146Ethyl 3-mercapto-4-cyclohexylphenylglyoxylate

Product 1

HCID 20515167HCID 20515167, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

To 3.85 g. of ethyl 3-mercapto-4-cyclohexylphenylglyoxylate in 40 ml. of water containing 0.65 g. of sodium hydroxide is added 2 ml. of dimethyl sulfate with stirring. The reaction mixture is gradually warmed to 40° C and stirred for 2 hours. The mixture is cooled and extracted with ether which is washed with water, dried and evaporated in vacuo. The residue is distilled to obtain ethyl 3-methylthio-4-cyclohexylphenylglyoxylate.

Workup

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether which
  3. washis washed with water
  4. customdried
  5. customevaporated in vacuo
  6. distillationThe residue is distilled

Sources & evidence

ORD record
ord-33330351d8e049409f769bcd3be1ff36
Source dataset
uspto-grants-1978_06
Patent number
US04096279

Reaction notes

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