Hydrochloric Acid → HCID 88781849, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-(4-chlorophenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone (2.95 g., 0.00863 mole), potassium carbonate (2.26 g., 0.0163 mole) and ethylbromoacetate (2.72 g., 0.0163 mole) in dimethylformamide (50 ml.) is warmed at 55°-60° C. for 2 hours, then treated with water (50 ml.)-10N sodium hydroxide solution (2.5 ml., 0.025 mole) and heated at 80° C. for one hour. The reaction mixture is added slowly to water (500 ml.)-12N hydrochloric acid (10 ml.) to precipitate 1.37 g. of [1-oxo-2-(4-chlorophenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetic acid hemihydrate which melts at 141°-142° C. after crystallization from acetic acid:water, 1:1.

Provenance & Evidence