Dimethylformamide → HCID 178421592, compound

Participants

Reaction Steps

(1-Oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetonitrile (4.87 g., 0.014 mole), sodium azide (1.09 g., 0.0168 mole), ammonium chloride (0.90 g., 0.0168 mole) and dimethylformamide (30 ml.) are heated at 80° C. for 21/2 hrs. The reaction mixture is poured into water (500 ml.), the solution filtered and acidified with 6N hydrochloric acid to precipitate 2.60 g. of 5-(1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxymethyl)tetrazole which melts at 227°-229° C. after crystallization from ethanol.

Provenance & Evidence