Hydrochloric Acid → HCID 20378219, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-(4-cyanophenyl)-2-methyl-5-hydroxy-6,7-dichloro-1-indanone (1.8 g., 0.0054 mole), potassium carbonate (1.5 g., 0.0109 mole) and ethyl bromoacetate (1.8 g., 0.0109 mole) in dimethylformamide (60 ml.) is warmed at 55°-60° C. for 3 hours, then treated with water (60 ml.)-10N sodium hydroxide solution (3 ml., 0.03 mole) and heated at 100° C. for 1.5 hours. The reaction mixture is added slowly to ice-water (300 ml.)-12N hydrochloric acid (5 ml.) to precipitate 160 mg. of [1-oxo-2-(4-cyanophenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetic acid which melts at 184°-5° C. after crystallization from acetic acid: water, 1:1.

Provenance & Evidence