HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Indacrinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (1-Oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetonitrile | HCID 12423629 | — |
| Solvent | Water | HCID 962 | — |
| Product | Indacrinone | HCID 42266 | — |
Reaction Steps
A mixture of (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetonitrile (3.0 g.), Example 19, Step A, acetic acid (20 ml.), water (5 ml.) and concentrated sulfuric acid (5 ml.) is refluxed for 2 hours then poured into ice-water (100 ml.) affording 2.5 g. of (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid which melts at 168°-169° C. after recrystallization from acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04096267 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-2aaad639afc4481597fb70347165a0f1 |
| Source note | uspto-grants-1978_06 |