HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane → Indacrinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | Tert-butyl(1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetate | HCID 20384375 | — |
| Catalyst | Methanesulfonic Acid | HCID 6395 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Indacrinone | HCID 42266 | — |
Reaction Steps
A solution of tert-butyl (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetate (1.0 g., 0.00237 mole) in benzene (25 ml.) is treated with methanesulfonic acid (2 drops) and refluxed for 1/2 hour. The reaction mixture is treated with cyclohexane (20 ml.) and cooled affording (1-oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid which is filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04096267 |
| Source dataset | uspto-grants-1978_06 |
| ORD ID | ord-9b6fb8647ee448b6890fe50d8005cfe1 |
| Source note | uspto-grants-1978_06 |