HCID 13049036, compound → HCID 13049041, compound

HRID 839709Notes

Reaction equation

HRID 839709 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([O:13][CH2:14][CH2:15][N:16]([CH3:18])[CH3:17])[CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C>[CH3:17][N:16]([CH3:18])[CH2:15][CH2:14][O:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 13049036HCID 13049036, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 13049041HCID 13049041, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 10.0 g. (0.0402 mole) of 1-benzyl-3-(2-dimethylaminoethoxy)pyrrolidine in ethanol containing 10% palladium on charcoal was shaken at 60° C. in about three atmospheres of hydrogen until the theoretical amount of hydrogen was used. The cooled filtered solution was concentrated at reduced pressure to give a quantitative yield of oily product. The structure was confirmed by its nuclear magnetic resonance spectrum.

Workup

  1. filtrationThe cooled filtered solution
  2. concentrationwas concentrated at reduced pressure

Sources & evidence

ORD record
ord-096ec055e6e44f3288d495dbb45b1754
Source dataset
uspto-grants-1978_06
Patent number
US04096331

Reaction notes

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