1-Benzyl-3-(2-morpholinoethoxy)pyrrolidine → 4-[2-(Pyrrolidin-3-yloxy)ethyl]morpholine

Participants

Reaction Steps

A solution of 30.8 g. (0.106 mole) of 1-benzyl-3-(2-morpholinoethoxy)pyrrolidine in 200 ml. of ethanol containing 10% palladium on charcoal was shaken at 60° C. in about three atmospheres of hydrogen until the theoretical amount of hydrogen was used. Concentration of the cooled filtered solution at reduced pressure gave a quantitative yield of oily product. The structure was confirmed by its nuclear magnetic resonance spectrum.

Provenance & Evidence