Sodium Carbonate → HCID 20305135, compound

Participants

Reaction Steps

A mixture of 10 g (0.026 mol) of 2-chloro-2-[2-(3-carbomethoxypropyl)benzyl]-1,3-cyclohexanedione, VIIIb and 18.5 g (0.175 mol) of anhydrous Na2CO3 was refluxed in 200 ml xylene for 2 hours. Filtration and evaporation gave a brown oil (10 g). Evaporative distillation at 175° C/0.2 mm gave 6 g of a pale yellow oil. This was chromatographed on silica gel and eluted with 7:3 v:v CCl4 :acetone. Like fractions were combined to give 4.1 g of the keto ester IXb as a pale yellow oil.

Provenance & Evidence