17beta-(2-Cyanoethoxy)-1,3-diethoxyestra-1,3,5(10)-triene → 17beta-(2-Cyanoethoxy)-1,3-dimethoxyestra-1,3,5-(10)-triene

HRID 839750Notes

Reaction equation

HRID 839750 reaction equation
C(OC1C2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](O)CC4)CCC=2C=C(OCC)C=1)C.C(OC1C=C(OC)C2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](O)CC4)CCC=2C=1)C.COC1C2[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)[C@@H](O)CC4)CCC=2C=C(OC)C=1.[C:73]([CH2:75][CH2:76][O:77][C@H:78]1[CH2:83][CH2:82][C@H:81]2[C@H:84]3[C@H:93]([CH2:94][CH2:95][C@:79]12[CH3:80])[C:92]1[C:91]([O:96][CH2:97]C)=[CH:90][C:89]([O:99][CH2:100]C)=[CH:88][C:87]=1[CH2:86][CH2:85]3)#[N:74].C(CCO[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)C1C(OC)=CC(OCC)=CC=1CC3)#N>>[C:73]([CH2:75][CH2:76][O:77][C@H:78]1[CH2:83][CH2:82][C@H:81]2[C@H:84]3[C@H:93]([CH2:94][CH2:95][C@:79]12[CH3:80])[C:92]1[C:91]([O:96][CH3:97])=[CH:90][C:89]([O:99][CH3:100])=[CH:88][C:87]=1[CH2:86][CH2:85]3)#[N:74]

Participants

6

Reactant 5

HCID 5369505417beta-(2-Cyanoethoxy)-1,3-diethoxyestra-1,3,5(10)-trieneHCID 5456024817beta-(2-Cyanoethoxy)-3-ethoxy-1-methoxyestra-1,3,5(10)-trieneHCID 706143593-Ethoxy-17beta-hydroxy-1-methoxyestra-1,3,5(10)-trieneHCID 706144001,3-Dimethoxy-17beta-hydroxyestra-1,3,5(10)-trieneHCID 706147201,3-Diethoxy-17beta-hydroxyestra-1,3,5(10)-triene

Product 1

HCID 2280385717beta-(2-Cyanoethoxy)-1,3-dimethoxyestra-1,3,5-(10)-triene

Procedure

When in the above procedure 1,3-diethoxy-17β-hydroxyestra-1,3,5(10)-triene and 3-ethoxy-17β-hydroxy-1-methoxyestra-1,3,5(10)-triene are employed in place of 1,3-dimethoxy-17β-hydroxyestra-1,3,5(10)-triene, 17β-(2-cyanoethoxy)-1,3-diethoxyestra-1,3,5(10)-triene and 17β-(2-cyanoethoxy)-3-ethoxy-1-methoxyestra-1,3,5(10)-triene are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-b69af23b581c4319875b5c3bdb2710b2
Source dataset
uspto-grants-1978_06
Patent number
US04096253

Reaction notes

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