反应详情

To a suspension of 20 g of 2-amino-5-mercapto-1,3,4 -thiadiazole in 200 ml of pyridine was added 14.6 g of propionyl chloride with cooling over a 5 minute period. After stirring the reaction mixture for 4 hours at room temperature, water was added and the resulting solid collected by filtration to give 20.2 g of 2-propionamido-5-mercapto-1,3,4-thiadiazole, m.p. 234°-237° C.

1. temperaturewith cooling over a 5 minute period
2. filtrationthe resulting solid collected by filtration