Water → HCID 178460114, compound

HRID 839761Notes

Reaction equation

HRID 839761 reaction equation
[NH2:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[C:8](Cl)(=[O:11])[CH2:9][CH3:10].O>N1C=CC=CC=1>[C:8]([NH:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1)(=[O:11])[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 962WaterHCID 62324Propionyl chlorideHCID 178509208HCID 178509208, compound

Product 1

HCID 178460114HCID 178460114, compoundYield 71.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a suspension of 20 g of 2-amino-5-mercapto-1,3,4 -thiadiazole in 200 ml of pyridine was added 14.6 g of propionyl chloride with cooling over a 5 minute period. After stirring the reaction mixture for 4 hours at room temperature, water was added and the resulting solid collected by filtration to give 20.2 g of 2-propionamido-5-mercapto-1,3,4-thiadiazole, m.p. 234°-237° C.

Workup

  1. temperaturewith cooling over a 5 minute period
  2. filtrationthe resulting solid collected by filtration

Sources & evidence

ORD record
ord-4b090d5ad3484e02869f906ffea75189
Source dataset
uspto-grants-1978_06
Patent number
US04097263

Reaction notes

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