反应详情

To a stirred suspension of 6.0 g of 2-methylamino-5-(β-chloro-α,α-dimethylethyl)-1,3,4-thiadiazole in 100 ml of benzene was added 2.0 g of methyl isocyanate. The mixture became homogenous upon heating to reflux temperature and reflux was maintained for 2 hrs. After cooling, the benzene was removed at reduced pressure and the precipitate collected, giving 7.4 g (95%), m.p. 159°-161°. An analytical sample was prepared from methylene chloride-ether, m.p. 160°-161°.

1. temperatureupon heating
2. temperatureto reflux temperature
3. temperaturereflux
4. temperaturewas maintained for 2 hrs
5. temperatureAfter cooling
6. customthe benzene was removed at reduced pressure
7. customthe precipitate collected
8. customgiving 7.4 g (95%), m.p. 159°-161°