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Hydrogen Bromide → 2alpha-Bromo-5alpha-cholestan-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 5alpha-Cholestan-3-one | HCID 92128 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2alpha-Bromo-5alpha-cholestan-3-one | HCID 223857 | — |
反応手順
50 g. of 5α-cholestan-3-one is dissolved in 750 ml. of acetic acid and 5000 ml. of ether, combined with 1 ml. of hydrobromic acid in acetic acid (37% strength), and gradually added dropwise to a solution of 22 g. of bromine in 50 ml. of acetic acid. The mixture is agitated for another 30 minutes, diluted with methylene chloride, and washed in succession with water, sodium bicarbonate solution, and water. After drying and evaporation, 61.5 g. of crude 2α-bromo-5α-cholestan-3-one is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04097334 |
| 出典データセット | uspto-grants-1978_06 |
| ORD ID | ord-c02d6ab0dfc34c0f8151e296a519c6db |
| 出典メモ | uspto-grants-1978_06 |