HCID 20321974, compound → HCID 20321972, compound

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Reaction Steps

2,5-Bis(2,2,2-trifluoroethoxy)-N-methyl-N-(2-pyridylmethyl)benzamide (0.015 mole, 6.33 g.) in 200 ml. of glacial acetic acid is mixed with 0.2 g. of platinum oxideacetic acid paste and the mixture is shaken on a Parr hydrogenation apparatus at a temperature of about 23° C. for about 3.5 hours. The resulting material is filtered and the filtrate is evaporated, toluene being added to form an azeotrope and facilitate evaporation. The residue of the evaporation is mixed with 5 percent sodium hydroxide solution and diethyl ether, and the organic layer is separated, washed with saturated sodium chloride solution, dried and evaporated to provide a white solid, 2,5-bis(2,2,2-trifluoroethoxy)-N-methyl-N-(2-piperidylmethyl)benzamide, m.p. 104°-107° C.

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