Isobutyric anhydride → HCID 20322014, compound

HRID 839794Notes

Reaction equation

HRID 839794 reaction equation
CC1C=C2C=CC=CN2N=1.C(OC(=O)C(C)C)(=O)C(C)C.[C:22]([C:27]1[C:28]([CH3:36])=[N:29][N:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=12)(=O)[CH:23]([CH3:25])[CH3:24]>S(=O)(=O)(O)O>[CH2:22]([C:27]1[C:28]([CH3:36])=[N:29][N:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=12)[CH:23]([CH3:25])[CH3:24]

Participants

5

Reactant 3

HCID 7346Isobutyric anhydrideHCID 15620341HCID 15620341, compoundHCID 200716242-Methyl-1-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1-propanone

Product 1

HCID 20322014HCID 20322014, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

2-Methylpyrazolo[1,5-a]pyridine was worked up according to the same process as shown in example 1, with an excess isobutyric anhydride in the presence of 2-3 drops of concentrated sulfuric acid to prepare 3-isobutyryl-2-methylpyrazolo[1,5-a]pyridine (139-140°/5 mmHg). Yield 40%.

Sources & evidence

ORD record
ord-63f70b4ee1244ea0ace67cf5731b45cc
Source dataset
uspto-grants-1978_06
Patent number
US04097483

Reaction notes

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