Ethanol → HCID 54351148, compound

Participants

Reaction Steps

145 g of crude 4-methylpimelic acid, 68 ml of absolute ethanol and 12 ml of concentrated sulfuric acid were refluxed for 5 hours. The mixture was poured onto ice and extracted several times. The combined ether solutions were extracted with saturated NaHCO3 until the development of CO2 was finished. The aqueous extracts were covered with a layer of ether and adjusted while stirring to pH 2 to 3 with diluted sulfuric acid. The ether layer was separated and the aqueous phase was saturated with (NH4)2SO4 and extracted three times with ether.

Provenance & Evidence