N,N,1-trimethyl-1H-pyrrole-2-carboxamide → isopropyl 5-(N-methyl-2-pyrroyl)-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylate
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[CH:8]([C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10])[CH2:7][CH2:6][N:5]2[CH:15]=1.CN(C)[C:18]([C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][CH:24]=1)=[O:19]>>[CH3:25][N:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[C:18]([C:15]1[N:5]2[CH2:6][CH2:7][CH:8]([C:9]([O:11][CH:12]([CH3:13])[CH3:14])=[O:10])[C:4]2=[CH:3][C:2]=1[CH3:1])=[O:19]Participants
3
Procedure
In accordance with the method of Example 8, isopropyl 1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate is condensed with N,N-dimethyl-1-methylpyrrole-2-carboxamide, to produce isopropyl 5-(N-methyl-2-pyrroyl)-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (XI, R and R1 = CH3, R2 = iC3H7).
Sources & evidence
- ORD record
- ord-25bb25be6ef64068bfd08de860534f79
- Source dataset
- uspto-grants-1978_06
- Patent number
- US04097579
Reaction notes
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