Sodium Hydroxide → HCID 86735806, compound

HRID 839894Notes

Reaction equation

HRID 839894 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]2=[CH:11][CH:10]=1)=[O:8].[OH-].[Na+:21]>CO>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([C:9]1[N:13]2[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]2=[CH:11][CH:10]=1)=[O:8].[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70480598HCID 70480598, compound

Product 1

HCID 86735806HCID 86735806, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 300 mg. of 5-(N-methyl-2-pyrroyl)-1,2 -dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of methanol is added 1 molar equivalent of sodium hydroxide, in the form of a 0.1N solution. The solvent is then evaporated under reduced pressure and the residue taken up in 2 ml. of methanol, followed by precipitation with ether, to yield crude sodium 5-(N-methyl -2-pyrroyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylate which can be crystallized from ethyl acetate-hexane.

Workup

  1. customThe solvent is then evaporated under reduced pressure
  2. customof methanol, followed by precipitation with ether

Sources & evidence

ORD record
ord-f8b89ea3b62a4f42ba3e447275bcd9d2
Source dataset
uspto-grants-1978_06
Patent number
US04097579

Reaction notes

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