Diethyl Ether → HCID 178514629, compound

HRID 839909Notes

Reaction equation

HRID 839909 reaction equation
[N:1]#[N:2].[CH:3]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[S:8][C:7]=2[CH:6]=[CH:5][C:4]=1[S:16]([NH:19][C@H:20]([C:28]([OH:30])=O)[CH2:21][CH2:22][CH2:23][NH:24][C:25](=[NH:27])[NH2:26])(=[O:18])=[O:17].C(OCC)C.S(Cl)([Cl:38])=O>>[N:1]#[N:2].[CH:3]1[C:11]2[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[S:8][C:7]=2[CH:6]=[CH:5][C:4]=1[S:16]([NH:19][C@H:20]([C:28]([Cl:38])=[O:30])[CH2:21][CH2:22][CH2:23][NH:24][C:25](=[NH:27])[NH2:26])(=[O:18])=[O:17]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 178514630HCID 178514630, compound

Product 1

HCID 178514629HCID 178514629, compound

Procedure

A suspension of 4.21 g of N2 -(2-dibenzothienylsulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry diethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry diethyl ether to give N2 -(2-dibenzothienylsulfonyl)-L-arginyl chloride.

Workup

  1. customresulted in a precipitate which
  2. filtrationwas collected by filtration
  3. washwashed several times with dry diethyl ether

Sources & evidence

ORD record
ord-551ca1062cdb4a6eac07d460064a8c91
Source dataset
uspto-grants-1978_06
Patent number
US04097591

Reaction notes

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