Hydrochloric Acid → HCID 54032578, compound

Participants

Reaction Steps

In 20 ml of tetrahydrofuran, 574 mg of lithium aluminium hydride w as suspended. To the suspension was added dropwise 20 ml of tetrahydrofuran solution containing 1.0 g of N-(cyclohexylmethoxycarbonyl)-tyrosine while stirring and cooling with ice. The mixture was stirred at room temperature for two hours. After addition of 5% hydrochloric acid, the mixture was concentrated in vacuo and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to dryness. The residue was dissolved in chloroform and subjected to column chromatography with 10 g of silicagel to give 322 mg of N-(cyclohexylmethoxycarbonyl)-tyrosinol.

Provenance & Evidence