Ethanol → Sodium N-(4-methoxybenzoyl)-phenylalanyltyrosinate

HRID 839943Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:34]=[CH:33][C:6]([C:7]([NH:9][C@H:10]([C:18]([NH:20][C@H:21]([C:30]([OH:32])=[O:31])[CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[O:19])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:8])=[CH:5][CH:4]=1.C(O)C.O.[OH-].[Na+:40]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C@H:10]([C:18]([NH:20][C@H:21]([C:30]([O-:32])=[O:31])[CH2:22][C:23]2[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=2)=[O:19])[CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:8])=[CH:33][CH:34]=1.[Na+:40]

Participants

Reactant 4

HCID 702Ethanol

HCID 962Water

HCID 14798Sodium Hydroxide

HCID 54084741N-(4-methoxybenzoyl)-phenylalanyltyrosine

Product 1

HCID 70615234Sodium N-(4-methoxybenzoyl)-phenylalanyltyrosinate

Procedure

To a solution of 0.9 g of N-(4-methoxybenzoyl)-phenylalanyltyrosine and 10 ml of ethanol, 10 ml of water was added. The mixture was adjusted to a pH of 8 with IN sodium hydroxide and concentrated to dryness. Sodium N-(4-methoxybenzoyl)-phenylalanyltyrosinate in the form of a powder was obtained.

Workup

concentrationconcentrated to dryness

Sources & evidence

ORD record: ord-2b5badcb3801446684be84200fba6c99
Source dataset: uspto-grants-1978_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04097608

Reaction notes

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