Perchloric Acid → HCID 67184114, compound

Participants

Role	Name	HCID	Charge
Reactant	Perchloric Acid	HCID 24247	—
Reactant	3-(2-{(3aS,5R,6S,6aS)-2,2-dimethyl-5-[2-(4-pyrimidin-5-ylphenyl)ethyl]tetrahydrofuro[2,3-d][1,3]dioxol-6-yl}ethyl)-1,2,3-benzotriazin-4(3H)-one	HCID 68763085	—
Solvent	Water	HCID 962	—
Solvent	Acetonitrile	HCID 6342	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	HCID 67184114	HCID 67184114	—

Reaction Conditions

Temperature	55 °C

Reaction Steps

Perchloric acid (0.2 mL) was added to a solution of the compound obtained from step l above (0.3 g) in acetonitrile (4 mL) and water (0.2 mL) at room temperature. The reaction mixture was heated to 55° C. for 30 minutes. The reaction mixture was then quenched using sodium bicarbonate solution. The solvents were evaporated under reduced pressure. The residue thus obtained was taken up in ethyl acetate and water. The organic layer was separated and washed with water and brine solution and dried over anhydrous sodium sulphate. The solvent was concentrated under reduced pressure to yield the title compound (0.25 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846910B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-769ce9bd32174e8c9ea7e68844bffc18
Source note	uspto-grants-2014_09