反应详情

11.1 g of the 2,4-diethyl-4-methyl-1,5-diazaspiro[5.5]undec-1-ene and 2.5 g of ammonium bromide were dissolved in 70 ml of methanol, and 45 ml of water were added thereto, with stirring. The mixture was then stirred at room temperature for 8 hours. After removing the methanol by evaporation under reduced pressure, the residue was distilled under reduced pressure, giving 7.4 g of 2-ethyl-2,5-dimethyl-1-azaspiro[5.5]undecan-4-one, bp 119° - 122° C/1.5 mmHg.

1. stirringThe mixture was then stirred at room temperature for 8 hours
2. customAfter removing the methanol
3. customby evaporation under reduced pressure
4. distillationthe residue was distilled under reduced pressure