Ethanol → 7,9-Diethyl-6,7,9-trimethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Participants

Reaction Steps

To a solution of 115 g of 2,6-diethyl-2,3,6-trimethyl-4-piperidone in 600 ml of 50% ethanol were added 168 g of ammonium carbonate and 57.8 g of potassium cyanide; the mixture was then heated at 60° - 70° C for 8 hours. The resulting mixture was then filtered and washed with water and cold methanol, after which the solvent was evaporated off, giving 78.0 g of Compound 1, mp 263° - 267° C (decomposition).

Provenance & Evidence