HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 840056Generated: October 31, 2026
Methyl trifluoroacetate → 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide
https://huagongshe.com/reaction/840056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl trifluoroacetate | HCID 9893 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Product | 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide | HCID 11094805 | 86% |
Reaction Steps
Propargylamine (Aldrich, 25 g, 0.45 mol) was added dropwise to methyl trifluoroacetate (Tokyo Chemical Industry Co., Ltd., 69.2 g, 0.54 mol) cooled to 0° C. They were allowed to react at 0° C. for two hours to afford 43.8 g (86.0%) of N-propargyltrifluoroacetamide after purification by vacuum distillation (23 mmHg, boiling point; 77° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06365350B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-7bf0b9edf94a422fbfe95b302b47f93e |
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| Source note | uspto-grants-2002_04 |
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