HCID 22621682, compound → HCID 22621659, compound

Temperature

85 °C

To a solution of 1.90 g of an equal mixture of 2-bromo-1,1-dipentyl-cyclopropane and 1,1-dipentyl-cyclopropane in 10 ml dimethylsulfoxide was added 0.818 g (0.00308 mol) of potassium t-butoxide. The resulting mixture was heated to 85° C. for 5 hours and then stirred at room temperature for 16 hours. To this was added 0.100 g of potassium t-butoxide. The resulting mixture was heated to 85° C. for 2 hours then cooled to room temperature. The reaction mixture was poured onto water and then extracted with diethyl ether. The resulting mixture was transferred to a separatory funnel and the phases were separated. The organic layer was dried over MgSO4 and filtered. The solvent was removed from the filtrate in vacuo to yield 1.90 g of 3,3-dipentyl-cyclopropene mixed in equal parts with 1,1-dipentyl-cyclopropane as an oil.

1. temperatureThe resulting mixture was heated to 85° C. for 2 hours
2. temperaturethen cooled to room temperature
3. additionThe reaction mixture was poured onto water
4. extractionextracted with diethyl ether
5. customThe resulting mixture was transferred to a separatory funnel
6. customthe phases were separated
7. dry with materialThe organic layer was dried over MgSO4
8. filtrationfiltered
9. customThe solvent was removed from the filtrate in vacuo

ORD record

ord-4ce06228bd824381a5382d778ff8f332

Source dataset

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06365549B2