HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 54348392, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Stannane, tributyl(1-ethoxyethenyl)- | HCID 619414 | — |
| Reactant | HCID 54452086 | HCID 54452086 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | HCID 54348392 | HCID 54348392 | 191.5% |
Reaction Steps
2.5 g (6.0 mmol) of 4,5-epoxy-17-methyl-3-trifluoromethanesulfonyloxymorphinan-6-one, 2.1 ml (6.2 mmol) of (1-ethoxyvinyl)tributyltin, 2 g (48 mmol) of LiCl, 0.42 g (0.6 mmol) of bis(triphenylphosphine)palladium(II) chloride and 0.63 g (2.4 mmol) of triphenylphosphine in 25 ml of dimethylformamide were treated as described in Preparation 2. The crude reaction mixture was purified by flash chromatography, eluting with a mixture CH2Cl2/MeOH/conc. NH4OH 90:7:0.7 respectively, yielding 1.95 g of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365594B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-54655f0de3c94a8c8ce6062da9ff2730 |
| Source note | uspto-grants-2002_04 |