Bromine → HCID 53700356, compound

Participants

Reaction Steps

3.1 g (11.4 mmol) of 4,5-epoxy-17-methylmorphinan-6-ol were dissolved in 150 ml of glacial acetic acid and 11.4 ml of a 1M solution of Br2 in AcOH were added dropwise. After 1 h, AcOH was removed in vacuo, the residue was taken up with water, the aqueous solution was brought to pH 7 with a saturated NAHCO3 solution and extracted with AcOEt. The organic phase was dried over NA2SO4, the solvent was removed in vacuo, yielding 3.6 g of the title product.

Provenance & Evidence