3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride → 3-(2-Chloro-6-fluorophenyl)-5-methyl-N-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazi-nyl]propyl]isoxazole-4-carboxamide

Participants

Reaction Steps

The title compound was synthesised according to the procedure described in Example 8 but using 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride instead of the crude 3-(4-fluorophenyl)isoxazole-4-carbonyl chloride and Compound 12B instead of Compound 8B. Washing the reaction mixture with 2 N sodium hydroxide, followed by the usual work-up and purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3) afforded the title compound (92%) as an oil.

Provenance & Evidence