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HRID840123

反应详情

EQUATION

反应方程式

HRID 840123 的结构方程式

REACTANTS

反应物

2
结构：Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)O
HCID77521

4-Isoxazolecarboxylic acid, 3-(2,6-dichlorophenyl)-5-methyl-

C11H7Cl2NO3

结构：NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1
HCID10567490

4-[2-(2,2,2-Trifluoroethoxy)phenyl]-1-piperazinepropanamine

C15H22F3N3O

PRODUCTS

生成物

1
结构：Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1
HCID23447884

未命名化合物

收率 75%

PROCEDURE

实验过程

The title compound was synthesised according to the procedure described in Example 1 but using 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carboxylic acid instead of 3-phenyl-5-methyliso-xazole-4-carboxylic acid and Compound 12B instead of Compound 1B. Extraction with diethyl ether followed by purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3) afforded the title compound (75%) as an oil.

WORKUP

后处理

  1. customThe title compound was synthesised
  2. extractionExtraction with diethyl ether
  3. customfollowed by purification by flash chromatography (chloroform-2 N ammonia in methanol 100:3)