HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10958012, compound → HCID 23447870, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10958012 | HCID 10958012 | — |
| Reactant | HCID 23447862 | HCID 23447862 | — |
| Reactant | 4-Chloro-2-(1-piperazinyl)phenol | HCID 23447881 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 23447870 | HCID 23447870 | 64% |
Reaction Steps
The title compound was obtained following the procedure described in Example 2 but substituting Compound 19A for Compound 2B and 1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine for 1-(2-hydroxy-5-chlorophenyl)piperazine. The crude was taken up with ethyl acetate and the crude was purified by flash chromatography (ethyl acetate-2 N ammonia in methanol 98:2) to afford the title compound (64%). M.p. 115-117° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365591B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-3c7db30817884b33ab8629dd4eba9a1e |
| Source note | uspto-grants-2002_04 |