HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-3-(3-methoxyphenyl)-2,1-benzisoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (3-Methoxyphenyl)acetonitrile | HCID 88310 | — |
| Reactant | 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane | HCID 15489626 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-[2-(4-Chlorophenyl)-1,3-dioxolan-2-yl]-3-(3-methoxyphenyl)-2,1-benzisoxazole | HCID 22714374 | 90% |
Reaction Steps
Sodium hydroxide (16.4 g) and (3 methoxyphenyl)acetonitrile (20.6 ml) were added at room temperature to a solution of interm. (5-a) (25 g) in methanol (100 ml) and the mixture was stirred at room temperature overnight. Water was added, the precipitate was filtered off, washed with cold methanol and dried. The product was used without further purification, yielding 30 g (90%) of 5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-3-(3-methoxyphenyl)-2,1-benzisoxazole (interm. 5-b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365600B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-b1f2e1d2d6b940368ec2734360b98d06 |
| Source note | uspto-grants-2002_04 |