HCID 70146254, compound → HCID 11034899, compound

Participants

Reaction Conditions

Reaction Steps

16α-Bromo-17,17-ethylenedioxy-androst-5-en-3β-ol 3-acetate from Example 28A (50.000 g, 110.28 mmol) is dissolved in dimethyl sulfoxide (DMSO; 500 mL) and the solution is warmed to 45° C. under an inert atmosphere. After 22 hours, the reaction is partitioned between ether (2000 mL) and water (750 mL). The layers are separated and the ether solution is washed with brine (2×500 mL), dried over MgSO4, filtered and evaporated to dryness. The residue is recrystallized from ethanol-water to afford the title compound.

Provenance & Evidence