HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 840258Generated: October 30, 2026
4-Piperidinecarboxylic acid → 1-Acetylpiperidine-4-carboxylic acid
https://huagongshe.com/reaction/840258
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Acetylpiperidine-4-carboxylic acid | HCID 117255 | 97% |
Reaction Steps
Isonipecotic acid (10 grams) (77.5 mmoles) and acetic anhydride (23.7 grams) (232.5 mmoles) were dissolved in MeOH (100 ml.) and the mixture was stirred at 25° C. for 24 hours. The mixture was evaporated to dryness and the residue was azeotroped with toluene to give the title compound (Yield: 12.8 grams, 97%, MH+ 172).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06365588B1 |
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| Source dataset | uspto-grants-2002_04 |
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| ORD ID | ord-f07dc6097e804481a08130b29f4a26fa |
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| Source note | uspto-grants-2002_04 |
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