3,5-Dimethylisoxazole-4-sulfonamide → N-(3,5-Dimethylisoxazol-4-ylsulphonyl)-6-[N-(5-bromo-2-(2-methylpropoxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

HRID 840294Notes

Reaction equation

HRID 840294 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[C:6]([CH:20]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]([OH:19])=O)=[CH:13][CH:12]=1)[CH2:9][CH3:10].[CH3:26][C:27]1[C:31]([S:32]([NH2:35])(=[O:34])=[O:33])=[C:30]([CH3:36])[O:29][N:28]=1>>[CH3:26][C:27]1[C:31]([S:32]([NH:35][C:17]([C:14]2[N:15]=[N:16][C:11]([N:8]([CH2:7][C:6]3[CH:20]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=3[O:21][CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:9][CH3:10])=[CH:12][CH:13]=2)=[O:19])(=[O:34])=[O:33])=[C:30]([CH3:36])[O:29][N:28]=1

Participants

3

Reactant 2

HCID 49623033,5-Dimethylisoxazole-4-sulfonamideHCID 226225576-[N-(5-Bromo-2-(2-methylpropoxy)benzyl)-N-ethylamino]pyridazine-3-carboxylic Acid

Product 1

HCID 22622516N-(3,5-Dimethylisoxazol-4-ylsulphonyl)-6-[N-(5-bromo-2-(2-methylpropoxy)benzyl)-N-ethylamino]pyridazine-3-carboxamide

Procedure

The title compound was prepared from 6-[5-bromo-2-(2-methylpropoxy)benzyl)-N-ethylamino]pyridine-3-carboxylic acid (example 9) and 3,5-dimethylisoxazol-4-ylsulphonamide using a similar method to that of example 14.

Sources & evidence

ORD record
ord-7a0b4471c1474aecac5a81c615e17f93
Source dataset
uspto-grants-2002_04
Patent number
US06365603B1

Reaction notes

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