Hydrochloric Acid → HCID 15477192, compound

Participants

Reaction Steps

In 20 ml of acetonitrile were dissolved 3.44 g of methyl acrylate and 0.62 g of t-butyl nitrite, and 0.65 g of copper (II) chloride was added. Under stirring, 1.16 g of N-(5-amino-4-chloro-2-fluorophenyl)phthalimide was added thereto in small portions, followed by stirring at room temperature for 1 hour. 3N Hydrochloric acid was added to the reaction mixture. After stirring, the reaction mixture was extracted with ethyl acetate. The organic layer was washed successively with water and a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate-hexane=1:5) to give 0.98 g of the title compound (No. 4 of Table 1).

Provenance & Evidence