Water → HCID 70176329, compound

Participants

Reaction Steps

In 20 ml of tetrahydofuran was dissolved 1.23 g of ethyl 2-chloro-3-(2-chloro-4-fluoro-5-phthalimidophenyl)propionate, and 0.69 g of 1,8-diazabicyclo[5.4.0]-7-undecene was slowly added thereto dropwise. After the addition, the stirring was continued at room temperature for 1.5 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed successively with water and a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform) to give 0.78 g of the title compound (No. 17 of Table 2).

Provenance & Evidence