Nitric Acid → HCID 22623284, compound

Participants

Reaction Steps

A mixture of 49.6 g of N-(4-chloro-2-fluorophenyl)phthalimide and 180 ml of concentrated sulfuric acid was cooled in an ice bath, and a mixed acid consisting of 22.7 g of 60% nitric acid and 18 ml of concentrated sulfuric acid was slowly added dropwise under stirring (reaction temperature<10° C.). After the dropwise addition, the stirring was continued under cooling in an ice bath for 1 hour and then at room temperature for 1 hour. The reaction mixture was poured into ice-water, and the precipitated solid was collected by filtration. The resulting solid was washed successively with water and methanol and dried under reduced pressure to give 57.2 g of the title compound.

Provenance & Evidence