HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 22623067, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 12192069 | HCID 12192069 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 22623067 | HCID 22623067 | — |
Reaction Steps
485 mg of 6-chloro-7-nitro-2-methyl-1,4-benzoxazin-3-one is stirred with 136 mg of imidazole and 332 mg of potassium carbonate in 15 ml of DMF with the addition of copper powder for 6 hours at 180° C. It is diluted with ethyl acetate, extracted with brine, and the organic phase is dried. The crude product is purified by column chromatography with ethyl acetate with the addition of ethanol. 88 mg results.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365736B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-aa44a61a87094b09ba485fdd6b773c51 |
| Source note | uspto-grants-2002_04 |