Hydrochloric Acid → HCID 22623061, compound

Participants

Reaction Steps

203.9 mg (0.474 mmol) of 2-methyl-3-amino-6-[2-(3-chlorobenzyl-tert-butyloxycarbonylamino)-ethyl]-2H-1,4-benzoxazine is mixed with 7 ml of an HCl in dioxane solution (4M) and stirred for three hours at room temperature. The precipitated product is suctioned off, and washed with toluene and with dichloromethane. After drying on the oil pump, 163.3 mg (85.5%) of the desired product is obtained as dihydrochloride.

Provenance & Evidence