反应详情

温度

70 °C

1.25 g (5.9 mmol) of (±)-2-methyl-3-oxo-6-chloromethyl-3,4-dihydro-2H-1,4-benzoxazine is dissolved in 12.5 ml of dimethyl sulfoxide, mixed with 0.804 g (11.8 mmol) of imidazole and stirred for 8 hours at 70° C. After stirring overnight at room temperature, the reaction mixture is spun on an oil pump until dry, and the residue is chromatographed on silica gel (mobile solvent: methylene chloride/ethanol). 940 mg (65.7%) of the desired imidazole compound is obtained, melting point 219-222° C.

1. stirringAfter stirring overnight at room temperature
2. customuntil dry
3. customthe residue is chromatographed on silica gel (mobile solvent: methylene chloride/ethanol)