HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyrimidine → N-((5S)-3-(4-(1-{Pyrimid-2yl}-1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | N-((5S)-3-(4-(1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide | HCID 20638827 | — |
| Product | N-((5S)-3-(4-(1-{Pyrimid-2yl}-1,2,5,6-tetrahydropyrid-4-yl)phenyl)-2-oxooxazolidin-5-ylmethyl)acetamide | HCID 18716145 | — |
Reaction Steps
Using an analogous procedure to that described in Example 25, the TFA salt of Example 2 was reacted on a 1.5 mM scale with 2-chloropyrimidine, to give the title compound. Yield=220 mg, 36%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06365751B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-8e6e6a553da8479b9fc9af80a53b0f92 |
| Source note | uspto-grants-2002_04 |