Acetyl chloride → HCID 18715614, compound

Participants

Reaction Steps

Acetyl chloride (0.060 g) was added to a solution of 4-(2-aminophenyl)-N-Boc-piperidine (0.070 g) (Example 21 sub-part (b)) and triethylamine (0.090 g) in DCM (2 mL) and stirred overnight. The reaction was diluted with Et2O and extracted sequentially with aqueous sodium bicarbonate and 1N HCl. The organic extract was dried and evaporated to give the title compound (0.070 g) as a colorless oil. MS m/z 341 (M+Na). 1H NMR (CDCl3) δ 7.26 (m, 4H), 7.69 (br, 1H), 4.15 (m, 2H), 2.67 (m, 3H), 2.23 (s, 3H), 1.75 (m, 4H), 1.48 (s, 9H).

Provenance & Evidence