3-Cyano-N-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl)-N-methyl-1-naphthamide → N-[2-(S)-(3,4-Dichlorophenyl)-4-[4-[2-(methylsulfonyl)-4-methoxyphenyl]-1-piperidinyl]-butyl]-N-methyl-3-cyano-1-naphthamide Hydrochloride

Participants

Reaction Steps

Using standard reductive amination conditions N-[2-(S)-(3,4-dichlorophenyl)-4-oxobutyl]-N-methyl-3-cyano-1-naphthamide (0.130 g) was reacted with 4-(2-methylsulfonyl-4-methoxyphenyl)piperidine (0.082 g) and the product (0.074 g) was converted to the hydrochloride salt. MS m/z 678 (M+H). 1H NMR (DMSO-d6) δ 10.57 (m, 1H), 8.62 (m, 1H), 8.10 (m, 1H), 7.95-7.00 (m, 10H), 3.83 (s, 3H), 3.32 (s, 3H), 3.64-1.65 (m, 19H).

Provenance & Evidence