1-(Piperidin-4-yl)-1,3-diazinan-2-one → HCID 70160348, compound

Participants

Reaction Steps

Using standard reductive amination conditions 4-(tetrahydro-2-oxo-1(2H)-pyrimidinyl)piperidine (Miller, S C; Jacobs, R T; Shenvi, A B. EP 739891) was reacted with N-[2-(4-chlorophenyl)-4-oxobutyl]-N-methyl-3-nitro-1-naphthamide [Example 3] and converted to the citrate salt. MS m/z 578 (M+H). Analysis for C31H36ClN5O4.1.0 C6H8O7.0.8 H2O: calculated: C, 56.64; H, 5.86; N, 8.92; found: C, 56.60; H, 5.74; N, 8.69.

Provenance & Evidence