Trifluoroacetic acid → HCID 10933529, compound

Participants

Reaction Steps

1-Benzyloxycarbonyl-4-[4-methoxy-2-methylthiophenyl]piperidine (Example 2) was N-deprotected using trifluoroacetic acid under standard conditions to give 4-[4-methoxy-2-methylthiophenyl]piperidine; 1H NMR (CDCl3) δ 7.15 (d, 1H), 6.76 (d, 1H), 6.69 (dd, 1H), 3.80 (s, 3H), 3.18 (dm, 2H), 3.01 (tt, 1H), 2.78 (td, 2H), 2.45 (s, 3H), 1.82 (dm, 2H), 1.66 (s, 1H), 1.58 (qd, 2H); MS m/z 238 (M+H).

Provenance & Evidence