反应详情

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. Stirring was carried out at room temperature for four hours, the reaction mixture was evaporated to dryness and the residue obtained was taken up in water and ethyl ether. The organic phase was separated by settling, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered. 4.9 g (81%) of the expected ester, with a melting point of 77°-78° C., were recovered.

1. customthe reaction mixture was evaporated to dryness
2. customthe residue obtained
3. customThe organic phase was separated
4. dry with materialdried over magnesium sulfate
5. customevaporated
6. customThe residue obtained
7. customwas triturated in heptane
8. filtrationfiltered
9. custom4.9 g (81%) of the expected ester, with a melting point of 77°-78° C., were recovered