HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha-Ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol → methyl N-methyl-4-[3-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]-2-pyrrolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha-Ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol | HCID 11817362 | — |
| Reactant | methyl 4-iodo-1-methyl-1H-pyrrole-2-carboxylate | HCID 21826247 | — |
| Product | methyl N-methyl-4-[3-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]-2-pyrrolecarboxylate | HCID 22619418 | — |
Reaction Steps
Following the basic procedure of Example 11(d), by reacting 2.9 g (12 mmol) of α-ethynyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenemethanol with 3.2 g (12.1 mmol) of methyl N-methyl-4-iodo-2-pyrrolecarboxylate, 2.8 g (61%) of the expected ester, with a melting point of 150°-152° C., were recovered by trituration in isopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06368608B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-c57b0ff86c4a410ca520956175b00a14 |
| Source note | uspto-grants-2002_04 |