HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-iodobenzoate → Methyl 4-[3-hydroxy-3-(4,4-dimethylthiochroman-6-yl)-1-propynyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-iodobenzoate | HCID 69273 | — |
| Reactant | alpha-Ethynyl-4,4-dimethyl-6-thiochromanmethanol | HCID 22619414 | — |
| Product | Methyl 4-[3-hydroxy-3-(4,4-dimethylthiochroman-6-yl)-1-propynyl]benzoate | HCID 22619407 | 68.2% |
Reaction Steps
Following the basic procedure of Example 11(d), by reacting 1.4 g (6 mmol) of α-ethynyl-4,4-dimethyl-6-thiochromanmethanol with 1.6 g (6 mmol) of methyl 4-iodobenzoate, 1.5 g (68%) of the expected ester was obtained in the form of an orange-colored oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06368608B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-2747924c3b134eb69feb96f896e8dc78 |
| Source note | uspto-grants-2002_04 |