Lithium Hydroxide → HCID 22619634, compound

Participants

Reaction Steps

To a solution of 875 mg of 7 (2.1 mmol) in 10 ml of freshly distilled THF was added a solution of 875 mg of lithium hydroxide in 10 ml of water and 5 ml of methanol. The reaction was allowed to stir at room temperature 18 hours and concentrated to remove THF and methanol. The aqueous residue was adjusted to pH 6 with 6N HCl. This was extracted with 3×100 ml of dichloromethane. The pH of the aqueous part was readjusted to 6 again after first extraction. The combined organic part was dried (Na2SO4) and concentrated to give 790 mg (2.0 mmol, 97%) of 8 as white amorphous solid.

Provenance & Evidence